Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC058
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-12-08 14:05
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment MADOPAR 250MG 1\2,1\4,1\2,1\4 MADOPAR HBS 125MG 2 X1

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 19 individuals with a value less than 0.57 were subsequently diagnosed with PD. That is, 45.24% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.57 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 18, 'TN': 13, 'TP': 24, 'FP': 17}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 27, 'TN': 24, 'TP': 15, 'FP': 6}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 41, 'TN': 30, 'TP': 1, 'FP': 0}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 13, 'TN': 9, 'TP': 29, 'FP': 21}

Test Battery Details

Circle

numCircles 8
timePerCircleMean 31.77
timePerCircleCoV 0.316059
timePerCircleSlope 0.0118411
meanError 1.62925
tremorFreq 6.54297
tremorRelPower 36.8399
tremorGyroAmpMean 0.0141256
tremorGyroAmpSlope -0.0014679
tremorGyroAmpCoV 0.432837
tremorCoordAmpMean 0.0278212
tremorCoordAmpSlope -0.000958371
tremorCoordAmpCoV 0.722242
tremorAccAmpMean 0.0179235
tremorAccAmpSlope -0.000618747
tremorAccAmpCoV 0.466139
tremorPcRelVar 0.864563
tremorPcX 0.65591
tremorPcY -0.754839

Circle Segment 1

Duration 25.72 s, Accuracy Estimate 1.614 (lower is better)

Circle Segment 2

Duration 31.84 s, Accuracy Estimate 1.611 (lower is better)

Circle Segment 3

Duration 29.92 s, Accuracy Estimate 1.325 (lower is better)

Circle Segment 4

Duration 27.24 s, Accuracy Estimate 1.329 (lower is better)

Circle Segment 5

Duration 55.56 s, Accuracy Estimate 2.673 (lower is better)

Circle Segment 6

Duration 26.32 s, Accuracy Estimate 1.247 (lower is better)

Circle Segment 7

Duration 24.8 s, Accuracy Estimate 1.614 (lower is better)

Circle Segment 8

Duration 32.76 s, Accuracy Estimate 1.62 (lower is better)

Spiral

numSpirals 4
timePerSpiralMean 72.56
timePerSpiralCoV 0.082403
timePerSpiralSlope -0.0284454
meanError 1.68878
tremorFreq 5.85938
tremorRelPower 29.9464
tremorGyroAmpMean 0.0271311
tremorGyroAmpSlope 0.000710348
tremorGyroAmpCoV 0.434575
tremorCoordAmpMean 0.0414996
tremorCoordAmpSlope -0.00128276
tremorCoordAmpCoV 0.574587
tremorAccAmpMean 0.0513396
tremorAccAmpSlope -2.22582e-05
tremorAccAmpCoV 0.170435
tremorPcRelVar 0.624112
tremorPcX 0.574456
tremorPcY 0.818536

Spiral Segment 1

Duration 74.72 s, Accuracy Estimate 1.532 (lower is better)

Spiral Segment 2

Duration 78.56 s, Accuracy Estimate 1.691 (lower is better)

Spiral Segment 3

Duration 64.4 s, Accuracy Estimate 1.638 (lower is better)

Spiral Segment 4

Duration 72.56 s, Accuracy Estimate 1.894 (lower is better)

Elel

eDurationMean 1.03366
eDurationStd 0.203409
eDurationStdnorm 0.196785
eDurationMedian 0.97
eDurationQuartdelta 0.2725
eDurationQuartdeltanorm 0.280928
eDurationKurt 2.60456
eDurationTrenddiff -0.165
eDurationTrendratio 0.851351
eWidthMean 4.15207
eWidthStd 1.17121
eWidthStdnorm 0.282077
eWidthMedian 3.861
eWidthQuartdelta 1.3455
eWidthQuartdeltanorm 0.348485
eWidthKurt 3.80987
eWidthTrenddiff 0.2925
eWidthTrendratio 1.07692
eHeightMean 8.96049
eHeightStd 2.41386
eHeightStdnorm 0.269389
eHeightMedian 8.658
eHeightQuartdelta 2.457
eHeightQuartdeltanorm 0.283784
eHeightKurt 5.45981
eHeightTrenddiff -1.287
eHeightTrendratio 0.858065
eAspectMean 0.476232
eAspectStd 0.125788
eAspectStdnorm 0.264133
eAspectMedian 0.451613
eAspectQuartdelta 0.174077
eAspectQuartdeltanorm 0.385456
eAspectKurt 3.08182
eAspectTrenddiff 0.025769
eAspectTrendratio 1.0593
eSlantMean -0.0756988
eSlantStd 0.170183
eSlantStdnorm -2.24816
eSlantMedian -0.0789474
eSlantQuartdelta 0.279771
eSlantQuartdeltanorm -3.54377
eSlantKurt 1.89212
eSlantTrenddiff 0.0662023
eRtopMean 0.533361
eRtopStd 0.148708
eRtopStdnorm 0.278813
eRtopMedian 0.5
eRtopQuartdelta 0.246762
eRtopQuartdeltanorm 0.493524
eRtopKurt 2.34843
eRtopTrenddiff 0.0869548
eRbotMean 0.737054
eRbotStd 0.301839
eRbotStdnorm 0.409521
eRbotMedian 0.666667
eRbotQuartdelta 0.464142
eRbotQuartdeltanorm 0.696213
eRbotKurt 2.52572
eRbotTrenddiff -0.11394
eRrightMean 0.775475
eRrightStd 0.0802031
eRrightStdnorm 0.103425
eRrightMedian 0.76087
eRrightQuartdelta 0.102884
eRrightQuartdeltanorm 0.135219
eRrightKurt 2.56956
eRrightTrenddiff 0.00752685
eRleftMean 0.481976
eRleftStd 0.177088
eRleftStdnorm 0.36742
eRleftMedian 0.487805
eRleftQuartdelta 0.217205
eRleftQuartdeltanorm 0.44527
eRleftKurt 2.74545
eRleftTrenddiff -0.0860577
lDurationMean 1.46486
lDurationStd 0.281877
lDurationStdnorm 0.192425
lDurationMedian 1.475
lDurationQuartdelta 0.44
lDurationQuartdeltanorm 0.298305
lDurationKurt 2.458
lDurationTrenddiff -0.2375
lDurationTrendratio 0.853846
lWidthMean 4.68632
lWidthStd 1.34506
lWidthStdnorm 0.287018
lWidthMedian 4.446
lWidthQuartdelta 1.72575
lWidthQuartdeltanorm 0.388158
lWidthKurt 2.73842
lWidthTrenddiff -0.6435
lWidthTrendratio 0.865854
lHeightMean 19.5485
lHeightStd 2.45412
lHeightStdnorm 0.12554
lHeightMedian 19.422
lHeightQuartdelta 3.18825
lHeightQuartdeltanorm 0.164157
lHeightKurt 3.00711
lHeightTrenddiff -0.936
lHeightTrendratio 0.952941
lAspectMean 0.240484
lAspectStd 0.0644266
lAspectStdnorm 0.267904
lAspectMedian 0.228916
lAspectQuartdelta 0.102614
lAspectQuartdeltanorm 0.44826
lAspectKurt 2.27827
lAspectTrenddiff -0.0295485
lAspectTrendratio 0.875686
lSlantMean 0.0145635
lSlantStd 0.0834562
lSlantStdnorm 5.73051
lSlantMedian 0.0126582
lSlantQuartdelta 0.131181
lSlantQuartdeltanorm 10.3633
lSlantKurt 2.16859
lSlantTrenddiff 0.0277961
lRtopMean 0.664847
lRtopStd 0.139283
lRtopStdnorm 0.209497
lRtopMedian 0.690476
lRtopQuartdelta 0.1365
lRtopQuartdeltanorm 0.19769
lRtopKurt 3.62454
lRtopTrenddiff 0.00556418
lRbotMean 0.679337
lRbotStd 0.308926
lRbotStdnorm 0.454746
lRbotMedian 0.611111
lRbotQuartdelta 0.414309
lRbotQuartdeltanorm 0.67796
lRbotKurt 4.19726
lRbotTrenddiff -0.106654
lRrightMean 0.850514
lRrightStd 0.0611993
lRrightStdnorm 0.0719557
lRrightMedian 0.85443
lRrightQuartdelta 0.0817226
lRrightQuartdeltanorm 0.0956458
lRrightKurt 3.39547
lRrightTrenddiff -0.00829262
lRleftMean 0.308354
lRleftStd 0.150482
lRleftStdnorm 0.488019
lRleftMedian 0.281768
lRleftQuartdelta 0.178866
lRleftQuartdeltanorm 0.634797
lRleftKurt 3.87851
lRleftTrenddiff -0.0674667

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

Elel Segment 12

Elel Segment 13

Elel Segment 14

Elel Segment 15

FITTS Short Modified

meanTouchScore 0.857764
sumTouchScores 10.2932
meanMovementTime 1.32545
numTouches 12
undershootPercentage 0
overshootPercentage 8.33333

FITTS Long Modified

meanTouchScore 0.976986
sumTouchScores 10.7468
meanMovementTime 1.628
numTouches 11
undershootPercentage 0
overshootPercentage 0

ZigZag

numZigzags 3
timePerZigzagMean 77.92
timePerZigzagCoV 0.0582666
timePerZigzagSlope -0.0287474
meanError 2.13372
tremorFreq 5.95703
tremorRelPower 30.4626
tremorGyroAmpMean 0.0615202
tremorGyroAmpSlope -0.00278337
tremorGyroAmpCoV 1.76219
tremorCoordAmpMean 0.0405419
tremorCoordAmpSlope 0.00234142
tremorCoordAmpCoV 0.430186
tremorAccAmpMean 0.062696
tremorAccAmpSlope -0.00396148
tremorAccAmpCoV 1.53224
tremorPcRelVar 0.777995
tremorPcX -0.161974
tremorPcY -0.986795

ZigZag Segment 1

Duration 77.88 s, Accuracy Estimate 2.2 (lower is better)

ZigZag Segment 2

Duration 82.48 s, Accuracy Estimate 2.014 (lower is better)

ZigZag Segment 3

Duration 73.4 s, Accuracy Estimate 2.187 (lower is better)

ZigZag Offset

numZigzags 4
timePerZigzagMean 29.68
timePerZigzagCoV 0.118665
timePerZigzagSlope 0.00296496
zigzagHeightMean 54.1917
zigzagHeightCoV 0.069808
zigzagHeightSlope -0.00698326
meanError 0.0603595
tremorFreq 5.37109
tremorRelPower 37.2144
tremorGyroAmpMean 0.079072
tremorGyroAmpSlope -0.00639086
tremorGyroAmpCoV 1.71246
tremorCoordAmpMean 0.0554046
tremorCoordAmpSlope 0.00178896
tremorCoordAmpCoV 0.296941
tremorAccAmpMean 0.0854082
tremorAccAmpSlope -0.00868898
tremorAccAmpCoV 1.71587
tremorPcRelVar 0.710677
tremorPcX -0.424052
tremorPcY 0.905638

ZigZag Offset Segment 1

Duration 27.16 s, Accuracy Estimate 0.051 (lower is better)

ZigZag Offset Segment 2

Duration 34.56 s, Accuracy Estimate 0.112 (lower is better)

ZigZag Offset Segment 3

Duration 27.04 s, Accuracy Estimate 0.027 (lower is better)

ZigZag Offset Segment 4

Duration 29.96 s, Accuracy Estimate 0.052 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘PD’, ‘HiSpec_score’: 0.28}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.57}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.5777866991421454}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.924857827264693}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.5154409119871751}